Ap-1 Transcription Factor in Cell Differentiation and Survival
نویسندگان
چکیده
9 REVIEW OF LITERATURE 10 1. Signal transduction 10 1.1. Signaling during cell growth, differentiation, and apoptosis 10 1.2. Transcritional regulation of gene expression 11 2. Mitogen activated protein kinases (MAPKs) 11 2.1. ERK MAPKs 13 2.2. JNK MAPKs 15 2.3. p38 MAPKs 16 2.4. Transcriptional regulation by MAPKs 16 3. AP-1 transcription factor 17 3.1. AP-1 transcription factor family 17 3.2. c-Jun 18 3.2.1. Structure of c-Jun 18 3.2.2. Expression of c-Jun 19 3.2.3. Activation and regulation of c-Jun 19 3.3 Other Jun proteins 21 3.4. c-Fos 22 3.4.1. Structure of c-Fos 22 3.4.2. Expression of c-Fos 22 3.4.3. Activation and regulation of c-Fos 22 3.5 Other Fos proteins 23 3.6. Putative AP-1 target genes 24 4. AP-1 during cell growth, differentiation, and organ development 25 5. The role of AP-1 in apoptosis 27 6. AP-1 and tumorigenesis 28 AIMS OF THE STUDY 30 MATERIALS AND METHODS 31 1. Cell culture and treatments 31 2. Expression analyses 32 TABLE OF CONTENTS
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